We use Uber everywhere in the world including Mexico. Have done so for years and have never had a bad or even mildly unpleasant experience..they are generally outstanding.
Our recent trip from GDL to west Ajijic was 174 pesos. Taxi.was quoted at 500 pesos. It was easy to get picked up - just crossed the road from the terminal and waited a few minutes outside the OXXO.
I'm sure the OP knows Uber is not big black cars so highly unlikely to.suffer the fate of the cardinal, an incident that happened many years ago.
However you have not been able to get an Uber in the lakeside area. Ive just looked at the app and it appears that now, Uber SUV may be operating here although as it is very early morning no cars are available. Will have to check later as this would be great!