We drive up to Tlaquepaque at least once a week. The construction work is proceeding furiously, and things change almost every day.
As far as the airport, little has changed so far. But they plan to create some kind of new "tunnel" exchange at the airport, and when they start on that, it could make a big mess.
North of the airport is where the major construction is. Lanes come and go, there are construction vehicles crossing the road, some lanes are a meter or two above/below the lane adjacent (!) as they physically "move" the highway, and nothing is marked, adding to the confusion. All it takes is a small mistake, a fender-bender, and traffic stops. There is no way to predict this. My advice driving this route is to go slow and stay all the way to the right. The newest lanes (with the high-stress concrete) are where the lateral lanes used to be, and they are the most consistent, two lane sections of the highway (right now). At times, those lanes will take you around to the right of the pedestrian overpasses, which are still standing and must be removed. They also go around to the right of the returnos, so don't freak out and think if you're in the right lane you'll be forced off a returno. What the planners will eventually do with the returnos is known but to God.
My advice is to download the Waze app on your phone, which gives real-time traffic conditions and directions. Check it out at the time of day/day you are going to go to the airport/Tlaquepaque for a few weeks before your trip, to get an idea of how long it will take. The day of your trip, check Waze out early and follow its instructions. We do this every week, and haven't missed an appointment in Guad yet (gracias a Dios)